The Cytotoxic Effects of Datura Stramonium Plant on Liver in Laboratory Rats

Abstract

The goal of this study is to demonstrate the pathological effects of Datura extract on liver tissue as well as some physiological, biochemical, and haematological indicators in laboratory rats. When the animals were given the Datura plant filtrate, which contains many special and effective compounds, it caused histopathological changes in the liver tissue, such as dilatation and congestion in the central vein, expansion and congestion in the sinusoids, severe fatty infiltration in the liver cells, necrosis of the hepatocytes, endothelial cell necrosis, and vacuolar degeneration in large areas of the liver compared to the control. The current study found a significant reduction in blood and biochemical parameters when compared to the control group.