eng Journal of Medical Research and Health Sciences 2589-9031 4 https://doi.org/10.15520/jmrhs.v4i3.319 article The global pandemic of COVID-19 has created historic and devastating impact. The pathophysiology and adverse clinical effects, are attributed to the uncontrolled inflammatory cascades and immune responses attributed to a “cytokine storm”. Melatonin has shown its role in anti-inflammation, antioxidant, and immunomodulation and proposes potential therapeutic tool against COVID-19. The clinical data and safety profile of melatonin in COVID-19 are currently under prospective evaluation, however, its efficacy in diseases with chronic inflammation and other viral infections propose potential current benefits of melatonin for COVID-19 infection and sequelae .pdf